WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for the enriched GO category are listed in this table. For each GO category, the first row lists its sub-root (biological process, molecular function, or cellular component), category name, and corresponding GO ID.
The second row lists the following statistics:
Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:biological process       Name:muscle contraction       ID:GO:0006936
C=254; O=7; E=0.33; R=21.22; rawP=1.85e-08; adjP=4.94e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107796 NA ACTA2 actin, alpha 2, smooth muscle, aorta 59 ENSG00000107796
2  ENSG00000163017 NA ACTG2 actin, gamma 2, smooth muscle, enteric 72 ENSG00000163017
3  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
4  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
5  ENSG00000163431 NA LMOD1 leiomodin 1 (smooth muscle) 25802 ENSG00000163431
6  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392
7  ENSG00000196557 NA CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 8912 ENSG00000196557


Database:biological process       Name:muscle system process       ID:GO:0003012
C=283; O=7; E=0.37; R=19.05; rawP=3.89e-08; adjP=5.19e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107796 NA ACTA2 actin, alpha 2, smooth muscle, aorta 59 ENSG00000107796
2  ENSG00000163017 NA ACTG2 actin, gamma 2, smooth muscle, enteric 72 ENSG00000163017
3  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
4  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
5  ENSG00000163431 NA LMOD1 leiomodin 1 (smooth muscle) 25802 ENSG00000163431
6  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392
7  ENSG00000196557 NA CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 8912 ENSG00000196557


Database:biological process       Name:smooth muscle contraction       ID:GO:0006939
C=80; O=4; E=0.10; R=38.50; rawP=3.02e-06; adjP=0.0003
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107796 NA ACTA2 actin, alpha 2, smooth muscle, aorta 59 ENSG00000107796
2  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
3  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
4  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392


Database:biological process       Name:system process       ID:GO:0003008
C=1695; O=10; E=2.20; R=4.54; rawP=1.46e-05; adjP=0.0010
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000077943 NA ITGA8 integrin, alpha 8 8516 ENSG00000077943
3  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
4  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
5  ENSG00000163431 NA LMOD1 leiomodin 1 (smooth muscle) 25802 ENSG00000163431
6  ENSG00000196557 NA CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 8912 ENSG00000196557
7  ENSG00000107796 NA ACTA2 actin, alpha 2, smooth muscle, aorta 59 ENSG00000107796
8  ENSG00000172201 NA ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 3400 ENSG00000172201
9  ENSG00000163017 NA ACTG2 actin, gamma 2, smooth muscle, enteric 72 ENSG00000163017
10  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392


Database:biological process       Name:negative regulation of astrocyte differentiation       ID:GO:0048712
C=13; O=2; E=0.02; R=118.46; rawP=0.0001; adjP=0.0053
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000140538 NA NTRK3 neurotrophic tyrosine kinase, receptor, type 3 4916 ENSG00000140538
2  ENSG00000172201 NA ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 3400 ENSG00000172201


Database:biological process       Name:muscle structure development       ID:GO:0061061
C=450; O=5; E=0.58; R=8.56; rawP=0.0002; adjP=0.0089
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000077943 NA ITGA8 integrin, alpha 8 8516 ENSG00000077943
2  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
3  ENSG00000149591 NA TAGLN transgelin 6876 ENSG00000149591
4  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392
5  ENSG00000196557 NA CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 8912 ENSG00000196557


Database:biological process       Name:smooth muscle tissue development       ID:GO:0048745
C=21; O=2; E=0.03; R=73.33; rawP=0.0003; adjP=0.0114
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000077943 NA ITGA8 integrin, alpha 8 8516 ENSG00000077943
2  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534


Database:biological process       Name:negative regulation of glial cell differentiation       ID:GO:0045686
C=25; O=2; E=0.03; R=61.60; rawP=0.0005; adjP=0.0134
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000140538 NA NTRK3 neurotrophic tyrosine kinase, receptor, type 3 4916 ENSG00000140538
2  ENSG00000172201 NA ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 3400 ENSG00000172201


Database:biological process       Name:regulation of cell growth       ID:GO:0001558
C=295; O=4; E=0.38; R=10.44; rawP=0.0005; adjP=0.0134
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000136999 NA NOV nephroblastoma overexpressed 4856 ENSG00000136999
2  ENSG00000140538 NA NTRK3 neurotrophic tyrosine kinase, receptor, type 3 4916 ENSG00000140538
3  ENSG00000103175 NA WFDC1 WAP four-disulfide core domain 1 58189 ENSG00000103175
4  ENSG00000173848 NA NET1 neuroepithelial cell transforming 1 10276 ENSG00000173848


Database:biological process       Name:regulation of astrocyte differentiation       ID:GO:0048710
C=23; O=2; E=0.03; R=66.96; rawP=0.0004; adjP=0.0134
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000140538 NA NTRK3 neurotrophic tyrosine kinase, receptor, type 3 4916 ENSG00000140538
2  ENSG00000172201 NA ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 3400 ENSG00000172201


Database:molecular function       Name:actin binding       ID:GO:0003779
C=356; O=5; E=0.47; R=10.73; rawP=7.75e-05; adjP=0.0057
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
3  ENSG00000163431 NA LMOD1 leiomodin 1 (smooth muscle) 25802 ENSG00000163431
4  ENSG00000149591 NA TAGLN transgelin 6876 ENSG00000149591
5  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392


Database:molecular function       Name:calcium-activated potassium channel activity       ID:GO:0015269
C=17; O=2; E=0.02; R=89.91; rawP=0.0002; adjP=0.0073
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113


Database:molecular function       Name:calcium activated cation channel activity       ID:GO:0005227
C=22; O=2; E=0.03; R=69.47; rawP=0.0004; adjP=0.0097
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113


Database:molecular function       Name:cytoskeletal protein binding       ID:GO:0008092
C=638; O=5; E=0.83; R=5.99; rawP=0.0011; adjP=0.0201
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
3  ENSG00000163431 NA LMOD1 leiomodin 1 (smooth muscle) 25802 ENSG00000163431
4  ENSG00000149591 NA TAGLN transgelin 6876 ENSG00000149591
5  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392


Database:molecular function       Name:serine-type endopeptidase inhibitor activity       ID:GO:0004867
C=95; O=2; E=0.12; R=16.09; rawP=0.0068; adjP=0.0621
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162267 NA ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 3699 ENSG00000162267
2  ENSG00000103175 NA WFDC1 WAP four-disulfide core domain 1 58189 ENSG00000103175


Database:molecular function       Name:cation channel activity       ID:GO:0005261
C=273; O=3; E=0.36; R=8.40; rawP=0.0051; adjP=0.0621
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
3  ENSG00000196557 NA CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 8912 ENSG00000196557


Database:molecular function       Name:ion gated channel activity       ID:GO:0022839
C=303; O=3; E=0.40; R=7.57; rawP=0.0068; adjP=0.0621
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
3  ENSG00000196557 NA CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 8912 ENSG00000196557


Database:molecular function       Name:gated channel activity       ID:GO:0022836
C=303; O=3; E=0.40; R=7.57; rawP=0.0068; adjP=0.0621
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
3  ENSG00000196557 NA CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 8912 ENSG00000196557


Database:molecular function       Name:peptidase regulator activity       ID:GO:0061134
C=206; O=2; E=0.27; R=7.42; rawP=0.0293; adjP=0.0622
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162267 NA ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 3699 ENSG00000162267
2  ENSG00000103175 NA WFDC1 WAP four-disulfide core domain 1 58189 ENSG00000103175


Database:molecular function       Name:ion channel activity       ID:GO:0005216
C=393; O=3; E=0.51; R=5.83; rawP=0.0139; adjP=0.0622
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
3  ENSG00000196557 NA CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 8912 ENSG00000196557


Database:cellular component       Name:smooth muscle contractile fiber       ID:GO:0030485
C=3; O=2; E=0.00; R=516.76; rawP=4.76e-06; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107796 NA ACTA2 actin, alpha 2, smooth muscle, aorta 59 ENSG00000107796
2  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392


Database:cellular component       Name:cation channel complex       ID:GO:0034703
C=132; O=3; E=0.17; R=17.62; rawP=0.0006; adjP=0.0150
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
3  ENSG00000196557 NA CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 8912 ENSG00000196557


Database:cellular component       Name:stress fiber       ID:GO:0001725
C=48; O=2; E=0.06; R=32.30; rawP=0.0017; adjP=0.0200
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
2  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392


Database:cellular component       Name:actin filament bundle       ID:GO:0032432
C=51; O=2; E=0.07; R=30.40; rawP=0.0019; adjP=0.0200
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
2  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392


Database:cellular component       Name:ion channel complex       ID:GO:0034702
C=203; O=3; E=0.26; R=11.46; rawP=0.0022; adjP=0.0200
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113
3  ENSG00000196557 NA CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 8912 ENSG00000196557


Database:cellular component       Name:actomyosin       ID:GO:0042641
C=57; O=2; E=0.07; R=27.20; rawP=0.0024; adjP=0.0200
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
2  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392


Database:cellular component       Name:potassium channel complex       ID:GO:0034705
C=70; O=2; E=0.09; R=22.15; rawP=0.0036; adjP=0.0225
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113


Database:cellular component       Name:voltage-gated potassium channel complex       ID:GO:0008076
C=70; O=2; E=0.09; R=22.15; rawP=0.0036; adjP=0.0225
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145936 NA KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 3779 ENSG00000145936
2  ENSG00000156113 NA KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 3778 ENSG00000156113


Database:cellular component       Name:actin cytoskeleton       ID:GO:0015629
C=365; O=3; E=0.47; R=6.37; rawP=0.0111; adjP=0.0617
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107796 NA ACTA2 actin, alpha 2, smooth muscle, aorta 59 ENSG00000107796
2  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
3  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392


Database:cellular component       Name:contractile fiber part       ID:GO:0044449
C=145; O=2; E=0.19; R=10.69; rawP=0.0148; adjP=0.0740
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107796 NA ACTA2 actin, alpha 2, smooth muscle, aorta 59 ENSG00000107796
2  ENSG00000133392 NA MYH11 myosin, heavy chain 11, smooth muscle 4629 ENSG00000133392




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).